Under glioma conditions, remodelling of the BBB leads to abnormal neogenesis of blood vessels and a residual intact blood-brain barrier, which brings new challenges to treatment.

2022年10月4日 · Assessing BBB alterations may help elucidate the complex role of the glioma TME and suggest new combination treatment strategies. We showed that TME-related pathways may regulate BBB alterations and that coinhibitory immune checkpoints were enriched in samples with higher BBB scores.

2023年9月22日 · Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai...

2024年9月25日 · The blood-brain barrier (BBB) serves as a crucial vascular specialization, shielding and nourishing brain neurons and glia while impeding drug delivery. Here, we conducted single-cell mRNA sequencing of human cerebrovascular cells from 13 surgically resected glioma samples and adjacent normal brain …

2021年5月27日 · In this review, we summarize the knowledge of remodelling of the BBB in the glioma environment, the type of changes that occur, and current BBB treatment methods and prospects for the treatment of glioma.

2023年5月29日 · Wang et al. developed a multifunctional bionic nanoplatform to deliver targeted photothermal–chemotherapy treatment for gliomas using a photothermal–chemotherapy device to overcome the inefficiency of traditional chemotherapy treatments caused by drug tolerance, nontargeting, and the blood–brain barrier (Ren et al. 2022). The ...

2024年10月1日 · FUS offers a promising approach by transiently disrupting the blood–brain barrier, thereby facilitating enhanced drug delivery to tumor cells while minimizing systemic side effects. A scoping review adhering to PRISMA guidelines was conducted to explore the literature on FUS-induced BBBD in glioma patients.

2024年5月1日 · In summary, we have developed a dual-functional peptide-modified liposome (DAT-LNP)/siRNA delivery system that can effectively target brain tumors through the blood–brain barrier (BBB) and induce tumor immune microenvironment activation for glioma immunotherapy.

2023年6月20日 · We report that contrast-enhancing (radiographically blood-brain barrier (BBB) disrupted) regions of high-grade gliomas (HGGs) exhibited a conserved extracellular metabolome across both IDH...

2004年1月1日 · The blood–brain barrier (BBB) is responsible for homeostasis of the microenvironment in the neural parenchyma and is essential for normal function of the brain. It protects the neuropil against neurotoxic compounds, the considerable variations in the composition of the blood, and against the breakdown of concentration gradients between blood ...