More from Immunity - Cell Press
We welcome studies that provide fundamental new immunological insights at the molecular, cellular, or whole organism level that are relevant, but not limited, to cancer, infectious …
Tissue-specific immunity for a changing world - Cell Press
Mar 18, 2021 · Understanding how immune responses by tissue-resident memory cells and other cells are impacted by evolving extrinsic elements such as diet, environment, and emerging …
CD4+ T cells re-wire granuloma cellularity and regulatory …
Aug 29, 2024 · Th1 CD4+ T cells mediate protective anti-Mtb immunity across biological systems and organisms. Bromley, Ganchua, et al. demonstrate that CD4+ T cells regulate immune …
Hypoxia-inducible factor 2α promotes pathogenic ... - Cell Press
Nov 27, 2024 · T helper 2 (Th2) cells orchestrate immunity against parasite infection and promote tissue repair but promote pathology in asthma and tissue fibrosis. Here, we examined the …
Sialylated IgG induces the transcription factor REST in ... - Cell Press
Notably, treatment of cells with sialylated IgG prior to the inflammatory stimulus rendered their transcriptomes indistinguishable from cells that were stimulated with asialylated IgGs only, …
Tumor-derived prostaglandin E2 programs cDC1 dysfunction
Jun 13, 2023 · Bayerl et al. reveal that PGE2 controls cDC1 function locally in tumors through the downregulation of IRF8, limiting cDC1-dependent anti-cancer CD8+ T cell responses, and …
The conceptual foundations of innate immunity: Taking ... - Cell Press
Apr 9, 2024 · Innate immunity is diverse and highly complex, with intricate crosstalk between its various levels and mechanisms, as illustrated, for instance, by the multilevel regulation …
SARS-CoV-2-infection- and vaccine-induced antibody ... - Cell Press
Mar 12, 2024 · SARS-CoV-2 mRNA-based vaccine-induced immunity is thought to wane quickly based on short-term studies. Using longitudinal data, Srivastava et al. find that participants …
Phase separation of chimeric antigen receptor promotes …
Dec 10, 2024 · CAR-T cells form disorganized immunological synapses. Xu et al. find that incorporation of the CD3ε module into CAR induces liquid-liquid phase separation, promoting …
Maintenance and functional regulation of immune memory to
Nov 6, 2024 · While vaccine-induced immunity circulates through blood, Davis-Porada et al. reveal that T and B cell memory generated by COVID-19 mRNA vaccines is stably maintained …