The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. ...

The most widely used classification of β-lactamases is the Ambler classification which divides β-lactamases into four classes (A, C, D, and B) based on their amino acid sequences. Ambler originally specified two classes (A and B) but later added C and D as new β-lactamases bore no resemblance to the existing class.

2024年10月7日 · Class D β-lactamases, often referred to as OXA-type enzymes, present a diverse and evolving challenge in the landscape of antibiotic resistance. These enzymes are particularly notorious for their ability to hydrolyze oxacillin and related penicillins, with certain variants also targeting carbapenems, which are typically reserved for serious ...

The updated system includes group 1 (class C) cephalosporinases; group 2 (classes A and D) broad-spectrum, inhibitor-resistant, and extended-spectrum β-lactamases and serine carbapenemases; and group 3 metallo-β-lactamases.

Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase.

2021年3月12日 · This review aims to describe the current class D β-lactamases including the functional groups, occurrence types (intrinsic or acquired) and substrate spectra and, focusing on the major OXA family, a new model for subfamily grouping will be presented.

2013年11月19日 · Among the most genetically diverse are the class D β-lactamases. In this class are β-lactamases that can inactivate the entire spectrum of β-lactam antibiotics (penicillins, cephalosporins, and carbapenems).

2024年10月7日 · Class D beta lactamases, also known as OXA-type enzymes, exhibit a unique ability to hydrolyze oxacillin and other penicillinase-resistant penicillins. These enzymes are predominantly found in Acinetobacter and Pseudomonas species, contributing to their multidrug-resistant profiles.

Class D beta-lactamase-mediated resistance to beta-lactams has been increasingly reported during the last decade. Those enzymes also known as oxacillinases or OXAs are widely distributed among Gram negatives.

β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives (), cephalosporins and cephamycins (), monobactams, carbapenems [1] and carbacephems. [2] Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group …