Phenotypes are artificial constructs, and in the case of asthma, it is useful for clinicians to characterize a particular subgroup of patients with asthma who define a particular risk factor, who respond to a particular treatment, or who have a particular good or bad prognosis.

To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links.

2025年1月22日 · Key Points. Question What is the clinical phenotype and natural history of patients with asymptomatic transthyretin (ATTR) cardiac amyloid infiltration?. Findings In this cohort study of 485 patients with asymptomatic ATTR cardiac amyloid infiltration, those with grade 2 or 3 cardiac uptake had greater rates of disease progression and a 5-fold higher risk of …

This paper summarizes the current clinical phenotypic classification of bronchiectasis from the perspective of etiology, microbiology, and the frequency of acute exacerbation, and cluster analysis was used to determine new clinical phenotypes and …

From the standpoint of the practicing physician, an important question is whether the clinical phenotype, particularly the occurrence of autoinflammation of autoimmunity, might suggest the likelihood of identifying a causative mutation, and if possible the gene most likely to …

2024年5月17日 · However, from a purely clinical perspective, a phenotype is defined as any clinically observable characteristic or trait of a disease. In a primary healthcare setting, a clinical...

In this review, we describe seven clinically meaningful COPD phenotypes that can be identified by the primary care provider as well as the specialist, and that carry specific management and prognostic implications.

We identified four distinctive IgG4-RD phenotypes according to organ involvement. Being Asian or female may predispose individuals to head and neck-limited disease. These phenotypes serve as a framework for identifying IgG4-RD and studying its aetiology and optimal treatment.

A phenotype (also often referred to as sub-phenotype) is a clinical entity defined by observable characteristics that is produced by an interaction between the genotype and the environment. The term is often used to describe subsets or subtypes on the basis of clinical or biochemical variables, natural history, disease manifestation, and/or ...

2024年8月26日 · Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid treatment.