2019年11月14日 · In titration, the medication is started at a low dose. Every couple of weeks, the dose is raised (“up-titrated”) until the maximum effective dose (“target dose”) has been achieved or side effects occur. Not everyone can tolerate a full dose. It’s safer to ease your way up.

Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [1] When a drug has a narrow therapeutic index, titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [2]

Drug titration is a way for clinicians to personalize medication doses so that patients can obtain the intended benefits of the treatment of their disease while minimizing side effects.

2024年10月18日 · Titration of a medicine means slowly increasing the dose of a medicine by very small amounts over days, weeks, or even months, to find the right dose that is effective for you. This allows your doctor to see how your body reacts …

2021年1月19日 · Despite the challenges associated with drug titration, it is a personalized approach to drug dosing that blends science with art, and with supportive real-world outcomes-based evidence, can be effective for optimizing pharmacotherapeutic outcomes …

For those patients who do not require an immediate response (hypertension, NIDDM, osteoarthritis, hyperlipidemia), start with a dose that is 1/4 to 1/2 the recommended starting dose in the CPS. Then titrate the daily dose every two to …

Herein, we quantify and characterize the use of response‐guided titration for drugs recently approved by the FDA to assess how frequently this dosing strategy is used and how titration regimens are evaluated during drug development.

2021年1月19日 · The scientific principles of drug titration, most commonly used for medications with a narrow therapeutic index, are to give the patient adequate and effective treatment, at the lowest dose possible, with the aim of minimizing unnecessary medication use and side effects.

2021年3月5日 · Many medications require dose titration to minimize adverse drug reactions (ADRs) or to reach a desired clinical effect or both. 1 Titrating doses with slow escalation over time allows for a customized regimen based on patient-specific treatment responses. 1,2

The drug titration paradox is an emerging concept in clinical pharmacology. The paradox refers to the observation that when drug is titrated to a specified level of effect in a population of patients, the expected positive correlation between dose and effect is reversed.