E3 ubiquitin ligases: styles, structures and functions
2021年7月30日 · E3 ubiquitin ligases play an essential role in catalyzing the ubiquitination process and transferring ubiquitin protein to attach the lysine site of targeted substrates. Importantly, ubiquitination modification is involved in almost all life activities of eukaryotes.
E3 ubiquitin ligases: styles, structures and functions - PubMed
2021年7月30日 · E3 ubiquitin ligases play an essential role in catalyzing the ubiquitination process and transferring ubiquitin protein to attach the lysine site of targeted substrates. Importantly, ubiquitination modification is involved in almost all life activities of eukaryotes.
Structural insights into the catalysis and regulation of E3 ubiquitin ...
2016年8月3日 · Ubiquitin ligases (E3s) recruit ubiquitin-conjugating enzyme (E2) ∼ ubiquitin (∼ denotes a thioester linkage; here, the linkage is between the catalytic cysteine of E2 and the carboxyl...
New insights into ubiquitin E3 ligase mechanism - Nature
2014年4月4日 · Three distinct classes of E3 ligases have been identified that stimulate transfer of ubiquitin and ubiquitin-like proteins through either a direct or an indirect mechanism. Only recently...
The E3 ubiquitin ligase CHIP in normal cell function and in …
E3 ubiquitin ligases, which are required for recognizing substrate proteins, comprise several structurally diverse groups in eukaryotic cells. 2 One type of E3 ligases are the U-box ubiquitin ligases (UULs).
Targeting E3 ubiquitin ligases and their adaptors as a therapeutic ...
2023年10月2日 · This review highlights the crucial role of E3 ubiquitin ligases and their adaptors in regulating metabolic diseases, such as obesity, diabetes, and nonalcoholic fatty liver disease.
Ubiquitin Ligases: Structure, Function, and Regulation
2017年6月20日 · Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases mediate the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to …
Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai
5 天之前 · Hakai protein (CBLL1 gene) was identified as an E3 ubiquitin ligase of E-cadherin complex, inducing its ubiquitination and degradation, thus inducing epithelial-to-mesenchymal transition. Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of ...
E3 ubiquitin ligases - PubMed
The selectivity of the ubiquitin-26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin-protein ligase (E3, of which there are possibly hundreds).
Ubiquitination of E3 ligases: self-regulation of the ubiquitin …
Here, we discuss how the biggest subfamily within the system, that of the E3 ubiquitin ligases that endow the system with its high specificity towards the numerous substrates, is regulated and in particular via self-regulation mediated by ubiquitin modification.
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