CLINICAL PHARMACOLOGY . Absorption . Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms. Following oral administration, metronidazole is well...
Metronidazole - StatPearls - NCBI Bookshelf
2023年6月26日 · Metronidazole is one of the mainstay drugs for the treatment of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. It is cytotoxic to facultative anaerobic microorganisms.
Pharmacokinetics and pharmacodynamics of the nitroimidazole ...
The pharmacokinetics of metronidazole are unaffected by acute or chronic renal failure, haemodialysis, continuous ambulatory peritoneal dialysis, age, pregnancy or enteric disease. Renal dysfunction reduces the elimination of metronidazole metabolites; however, no toxicity has been documented and dosage alterations are unnecessary.
Metronidazole: an update on metabolism, structure–cytotoxicity …
2017年10月25日 · Pharmacokinetics and pharmacodynamics of metronidazole in humans and murine models. Metronidazole is rapidly absorbed in humans, 61 mostly entering the gastrointestinal tract directly through the mucosa, rather than via the enterohepatic circulation. 62 Metronidazole is found in all tissues in mice and rats, after oral or intravenous ...
Clinical Pharmacokinetics of Metronidazole - Springer
2012年12月13日 · The clinical pharmacokinetics of metronidazole following oral, intravenous, rectal, and intravaginal doses are described. Peak serum concentrations are quite similar after oral or intravenous administration and average approximately 10 μg/ml after a single 500mg dose.
Clinical Pharmacology of Antibiotics - PMC - PubMed Central …
Pharmacologic considerations, including discussions of place in therapy, mechanism of action, pharmacokinetics, and pharmacodynamics, when prescribing commonly used classes of antibiotics in patients with CKD and ESKD will be reviewed.
Metronidazole: Mechanism, Activity, Pharmacokinetics, and …
2024年10月23日 · Understanding the pharmacokinetics of metronidazole provides insight into its therapeutic efficacy and safety profile. Once administered, metronidazole is rapidly absorbed, with oral formulations achieving peak plasma concentrations within one to two hours.
Flagyl® Oral Formulation Clinical Pharmacology
Pharmacokinetic modeling and simulation indicates the metronidazole dosage in amebiasis should be reduced by 50% and the dosage interval for trichomoniasis should be increased from every 12 hours to every 24 hours in patients with severe (Child-Pugh C) hepatic impairment.
Pharm 101: Metronidazole • LITFL • Top 200 Drugs
2020年8月18日 · Pharmacokinetics. PO/IV/suppository administration; Well absorbed; 99% bioavailability; Low protein binding 10-20%; Well distributed in tissues, including CSF; Hepatic metabolism; Renal excretion. Half-life 7.5 hours; Antimicrobial activity. Potent activity against anaerobes, including Bacteroides and Clostridium species; Clinical uses:
FLAGYL® (metronidazole) extended-release tablets, 750 mg
The optimum extended-release characteristics of FLAGYL ER 750 mg are obtained when the drug is taken under fasting conditions (see CLINICAL PHARMACOLOGY, Absorption). FLAGYL ER tablets should not be split, chewed, or crushed.