Glutathione metabolism and its implications for health
Glutathione plays important roles in antioxidant defense, nutrient metabolism, and regulation of cellular events (including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and immune response, and protein glutathionylation).
The Role of Glutathione Metabolism in Chronic Illness …
Glutathione stimulates vitamin D regulatory and glucose-metabolism genes, lowers oxidative stress and inflammation, and increases 25-hydroxy-vitamin D levels in blood: a novel approach to treat 25-hydroxyvitamin D deficiency.
Glutathione: Overview of its protective roles, measurement, and ...
This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of ...
Glutathione Metabolism - an overview | ScienceDirect Topics
Glutathione (64, Figure 22; GSH) is a thiol-containing tripeptide of major significance in the detoxification of drugs and other xenobiotics. In the body, it exists in a redox equilibrium between the reduced form (GSH) and an oxidized form (GSSG).
An Update on Glutathione's Biosynthesis, Metabolism, Functions, …
This review presents a current concept of the synthesis and metabolism of GSH; its main functions in a living organism, and as a precursor and cofactor; data on the use of GSH for medicinal purposes in the prevention and treatment of some diseases, as well as a nutritional strategy to maintain a normal pool of GSH in the body.
Glutathione Homeostasis and Functions: Potential Targets for …
Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles.
Glutathione metabolism | Pathway - PubChem
2019年1月29日 · Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids.
The glutathione cycle: Glutathione metabolism beyond the …
2018年4月17日 · This review briefly delineates the γ-glutamyl cycle as it was presented by Meister, discusses the shortcomings of the cycle, and finally presents a “glutathione cycle” that represents the current understanding of glutathione metabolism.
Glutathione Metabolism and Its Implications for Health
2003年12月5日 · Glutathione plays important roles in antioxidant defense, nutrient metabolism, and regulation of cellular events (including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and immune response, and protein glutathionylation).
Glutathione Metabolism - an overview | ScienceDirect Topics
Glutathione (γ-L-glutamyl-L-cysteinylglycine) is an important metabolite in plants, in particular because of its role in the response to oxidative stress. It is synthesized in two steps, by the action of γ-glutamylcysteine synthetase and glutathione synthetase, encoded in Chlamydomonas by the GSH1 and GSH2 genes, respectively.
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