Molecular Pathophysiology of Hepatic Glucose Production
Aberrant regulation of hepatic glucose production (HGP) can result in deleterious clinical outcomes, and excessive HGP is a major contributor to the hyperglycemia observed in Type 2 …
Regulation of hepatic glucose metabolism in health and disease
2017年7月21日 · Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this …
Liver glucose metabolism in humans - PMC - PubMed Central …
Hepatic glucose metabolism has an important role in glycosylation processes of proteins and lipids that has not been fully elucidated. PGM-1 catalyses the reversible interconversion of …
G12/13-mediated signaling stimulates hepatic glucose ... - Nature
2024年11月19日 · G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express GPCRs that can couple to G …
Hormonal Regulation Of Hepatic Glucose Production In Health …
Hepatic glucose production (HGP) is a key physiological process that becomes altered in diabetic patients (Bogardus et al., 1984) and represents the main target of the anti-hyperglycemic …
Hepatic glucose sensing and integrative pathways in the liver
2013年11月7日 · The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic …
Sympathetic circuits regulating hepatic glucose metabolism: …
2024年1月1日 · This review provides an overview of our current understanding of the hypothalamus-ventral brainstem-liver pathway involved in the sympathetic regulation of the …
Regulation of hepatic glucose metabolism in health and disease
Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this Review, we discuss …
Vps37a regulates hepatic glucose production by controlling …
2022年10月14日 · Using a Cy5-glucagon agonist, we show that the endosomal protein Vps37a uncouples glucose production from lipid usage downstream of Gcgr signaling by altering …
Molecular pathophysiology of hepatic glucose production
Aberrant regulation of hepatic glucose production (HGP) can result in deleterious clinical outcomes, and excessive HGP is a major contributor to the hyperglycemia observed in Type 2 …
Unraveling the Regulation of Hepatic Gluconeogenesis - PMC
Hepatic gluconeogenesis, de novo glucose synthesis from available precursors, plays a crucial role in maintaining glucose homeostasis to meet energy demands during prolonged starvation …
Hepatic glucose metabolism in humans—its role in health and …
2003年9月1日 · Hepatocytes take up glucose independently of insulin by the low-affinity high-capacity glucose transporter, GLUT-2, which facilitates the entry of glucose in the presence of …
Liver glucose metabolism in humans - PubMed
2016年11月29日 · Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose …
Increased hepatic gluconeogenesis and type 2 diabetes mellitus
2024年5月29日 · Lowering blood glucose levels by targeting hepatic gluconeogenesis is a promising strategy for the treatment of type 2 diabetes mellitus. The discovery of new …
Hormonal Regulation of Hepatic Glucose Production in Health …
2011年7月6日 · Hepatic glucose production (HGP) is a key physiological process that becomes altered in diabetic patients (Bogardus et al., 1984) and represents the main target of the …
RLO: The Physiology of the Liver - The Xerte Project
The liver helps maintain blood glucose levels in response to the pancreatic hormones insulin and glucagon. After a meal, glucose enters the liver and levels of blood glucose rise. This excess …
Targeting hepatic glucose output in the treatment of type 2 …
Here, we review the molecular mechanisms controlling hepatic gluconeogenesis and glycogen storage, and assess the prospect of therapeutically targeting associated pathways to treat type …
Hormonal Regulation of Hepatic Glucose Production in ... - Cell …
Hepatic glucose production (HGP) is a key physiological process that becomes altered in diabetic patients (Bogardus et al., 1984) and represents the main target of the antihyperglycemic effect …
Association between low fasting glucose of the living donor and …
4 天之前 · Glucose production in the liver, the principal organ responsible for glucose regulation, occurs via glycogenolysis and gluconeogenesis during fasting 6; however, in individuals with …
Hepatic glucose metabolism in the steatotic liver - PubMed
In this Review, we describe the dysregulation of hepatic glucose metabolism in MASLD and MASH and associated metabolic comorbidities, and how advances in techniques and models …
Regulation of Hepatic Glucose Uptake and Storage In Vivo
Elevated insulin concentrations, an increase in the load of glucose reaching the liver, and the oral/enteral/portal vein route of glucose delivery (compared with the peripheral intravenous …
We will review experimental evidence that insulin acts on glucose production by an extrahepatic (i.e., indirect) mechanism as well as by a direct hepatic effect. We will then provide our …
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