Experience 'Hotel Spero', a blend of history & modern charm, offering inventive cuisine & co-working spaces in the heart of San Francisco.

Hotel Spero marries distinctive San Francisco flair with the timeless beauty of Spanish Colonial architecture. In our lobby, we've carefully preserved historical features—such as hand-painted ceiling beams, original marble flooring, and ornate grillwork—seamlessly integrating them into a contemporary design.

As the vibrant energy of the city settles for the day, make your way back to the comforting embrace of your Spero hotel room. A sanctuary among San Francisco accommodations, warm ambient lighting, plush textiles, and chic geometric forms converge with cool designs and upscale touches to create a welcoming oasis.

We love to hear from our guests about their stay at Hotel Spero. If you have any questions or concerns about your upcoming reservation or have a special request, please feel free to contact us directly or through email.

From shipping a package to house rules for your doggie, and from check-in to check-out, we've thought of (mostly) everything you might want to know. Get answers to your most pressing questions and learn all the essential details about Hotel Spero before your arrival.

Discover versatile San Francisco meeting venues at our hotel, perfect for events from intimate dinners to vibrant receptions. Iconic encounters await.

Attending the JP Morgan Healthcare Conference? Stay at Hotel Spero for comfort and convenience. Book your stay today!

Hotel Spero Staff Picks showcase our favorite attractions, upcoming annual events, and gives the best advice on "must see" things to do in San Francisco.

Experience top things to do in San Francisco from Hotel Spero: visit Union Square, Golden Gate Bridge, Alcatraz, and more for a vibrant SF adventure.

The Hotel Spero has a unique San Francisco style with a historical Spanish Colonial design that's perfectly situated near Union Square in San Francisco.