In this article, we focus on the roles of IgE and MCs in host defense against parasites and review evidence that MCs and IgE-associated Th2 immunity can enhance host defenses against animal venoms.

In general, in the absence of specific symptoms or risk factors associated with specific parasitic infections, and without any travel history, screening for parasites, such as schistosomes or toxocara, in the setting of a total IgE = 15,300 and an absolute eosinophil count = 340 is not indicated for an individual residing in the United States

Using human hybridoma technology to immortalize IgE encoding B-cells from peripheral blood of subjects with filarial infections and elevated IgE, we generated naturally-occurring human IgE mAbs. B-cell cultures were screened in an unbiased manner for IgE production without regard to …

2022年8月23日 · In an interesting study in this issue of the Journal of Allergy and Clinical Immunology that was conducted using filarial infections as a demonstrator, Hadadianpour et al 5 identified major filarial antigens recognized by human IgE (hIgE) by using a labor-intensive technique previously applied for identification of Aspergillus antigens. 6 This ...

A hallmark of the immune response to parasite infection is immunoglobulin (Ig) E binding to Fc receptors on the surface of mast cells and basophils, leading to degranulation and secretion of inflammatory mediators [58,124,125].

2022年12月1日 · We used human monoclonal antibodies (mAbs) for an unbiased and comprehensive characterization of the immunodominant antigens targeted by IgE in conditions like allergy or helminth infection that are associated with elevated levels of IgE.

However, recent studies have provided evidence that, in addition to participating in host resistance to certain parasites, mast cells and IgE are critical components of innate (mast cells) and adaptive (mast cells and IgE) immune responses that can enhance host defense against the toxicity of certain arthropod and animal venoms, including ...

2014年2月13日 · Anti-parasite IgE has been associated with immunity against a range of helminth infections and many believe that IgE and its receptors evolved to help counter metazoan parasites. Allergens (IgE-antigens) are present in only a small minority of protein families and known IgE targets in helminths belong to these same families (e.g., EF-hand ...

2021年11月12日 · IgE is commonly believed to be associated with protection against a range of common parasites (‘worm hypothesis’), such as intestinal worms or blood flukes (Pritchard et al. 2020 ). An alternative or complementary hypothesis sees the function of IgE as protection against toxins (‘toxin hypothesis’) (Palm et al. 2012 ).

The current study investigated changes in parasite-specific IgG1, IgG4, and IgE responses to crude parasite extracts and defined allergen-like antigens following praziquantel and albendazole treatment of schoolchildren coinfected with schistosomes and hookworm and receiving treatment as part of a national control program.