A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words lactone + amide . Nomenclature

β-内酰胺类抗生素（Beta-lactam antibiotic）是一种种类很广的抗生素，其中包括 青霉素 及其衍生物、 头孢菌素 、 单酰胺环类 、 碳青霉烯类 和青霉烯类酶抑制剂等。

内酰胺（lactam）即环状的酰胺，由氨基羧酸除去水后生成的一种环酰胺，与内酰亚胺（lactim）是互变异构体 [1] [2] 。术语 lactam 是 lactone（内酯）与 amide（酰胺）的混成词。

β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in the terminal steps of peptidoglycan cross-linking in …

β-内酰胺（英語： β-lactam ）是一种四元内酰胺环 [1] ，内酰胺（Lactam）指环状的酰胺。因氨基在酰胺结构第β个碳原子上组成四元环，故称β-内酰胺。同理，若氨基在酰胺结构第γ、δ个碳原子上组成五元环、六元环，则分别称γ-内酰胺、δ-内酰胺。

β-Lactam or azetidin-2-one is an important structural motif of the penicillin, cephalosporin, carbapenem and carbecephem classes of antibiotics. 1 Naturally occurring as well as synthetic monobactams, such as nocardicins and tabtoxin, are also known for their unique antibacterial activities. 2–4 Besides their importance as the key structural ...

2023年12月6日 · While the formation of both the γ- and δ-lactam products (3.7:1 ratio) suggests that the enzyme’s regioselectivity could be tuned via protein engineering, these findings inspired us to steer ...

What is Lactam? A lactam is a cyclic amide, which is derived from an amino alkanoic acid. The term is a portmanteau of the words acetone + amide. Lactams form by the acid-catalysed rearrangement of oximes in the Beckmann rearrangement. Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction.

A lactam is a cyclic amide, which can be found in different forms: α-lactam (three-atom rings), β-lactam (four-atom rings), γ-lactam (five-atom rings), δ-lactam (six-atom rings), and ɛ-lactam (seven-atom rings). From: Green Approaches in Medicinal Chemistry for …

Lactam | C14H17NO3 | CID 53982816 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.