This comprehensive review explores the multifaceted landscape of inhaled nitric oxide (iNO) therapy, tracing its historical evolution, mechanisms of action, clinical applications, challenges, and future directions.

Nitric oxide (NO) is a naturally occurring vasodilator produced by vascular endothelial cells. Inhaled NO is currently approved for treatment of persistent pulmonary hypertension of the newborn (PPHN).

2023年8月28日 · Off-label, it is used to treat acute bronchiolitis and as rescue therapy in patients with COVID-19 and severe ARDS after other alternatives have failed. This activity describes the indications, mechanism of action, and contraindications for nitric …

2024年8月4日 · Nitric oxide or epoprostenol are best suited for prolonged maintenance therapy because they can be precisely titrated. Most hospital units will prefer one agent (typically either nitric oxide or epoprostenol).

Nitric oxide is used together with a breathing machine (ventilator) and other agents to treat newborn (term and near-term) babies with respiratory failure that is caused by pulmonary hypertension. Nitric oxide is a gas that is inhaled through the nose or mouth.

2004年6月29日 · Extracorporeal membrane oxygenation (ECMO) therapy is lifesaving for some infants with pulmonary hypertension; however, it is costly, invasive, and associated with important morbidities.

2005年12月22日 · Inhaled nitric oxide relaxes pulmonary vessels, thereby decreasing pulmonary vascular resistance, pulmonary arterial pressure, and right ventricular afterload (Table 1). 6–8 The selectivity...