p53 - Wikipedia
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in …
TP53 gene - MedlinePlus
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …
The TP53 Gene and Its Role in Cancer - Verywell Health
6 天之前 · TP53 is a protein whose main function is to repair DNA in order to prevent altered DNA from being passed on to daughter cells. When the damage in DNA is too extensive to be …
p53 signaling in cancer progression and therapy - BioMed Central
2021年12月24日 · In this review, we will discuss some of the molecular pathways by which mutant p53 proteins might perform their oncogenic activities, as well as prospective treatment …
The p53 Protein: From Cell Regulation to Cancer - CSHL P
If we are to understand the origins, treatment, and development of cancers in humans, both the basic and clinical functions of the p53 protein in normal and cancerous tissues must be …
Structure and Function of the p53 Tumor Suppressor Gene: Clues …
1996年10月16日 · The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle …
p53 Function and Dysfunction in Human Health and Diseases
2023年3月9日 · The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions …
p53: From Fundamental Biology to Clinical Applications in Cancer
2022年9月6日 · In this review, we describe and discuss the multifaceted roles of p53, from its discovery to clinical applications in cancer therapy. p53 tumour suppressor gene is our major …
A Different Facet of p53 Function: Regulation of Immunity and ...
2021年10月17日 · As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP 53) plays a central role in response to various cellular stresses. A variety …
Role of p53 in Cell Death and Human Cancers - MDPI
2010年12月7日 · p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered …