Proteasome - Wikipedia
The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.
The proteasome: Overview of structure and functions - PubMed …
The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated ...
The proteasome: structure, function, and role in the cell
The proteasome is a multisubunit enzyme complex that plays a central role in the regulation of proteins that control cell-cycle progression and apoptosis, and has therefore become an important target for anticancer therapy.
The Proteasome and its Role in the Nervous System - PubMed …
Proteasomes are multisubunit complexes that catalyze the majority of protein degradation in mammalian cells to maintain protein homeostasis and influence the regulation of most cellular processes. The proteasome, a multicatalytic protease complex, ...
Structure and Function of the 26S Proteasome - PubMed Central …
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome’s cellular functions range from general protein ...
Proteasome - an overview | ScienceDirect Topics
The proteasome mediates the degradation of many short-lived proteins that are involved in cell cycle regulation, signal transduction and apoptosis, and is also responsible for the recycling of abnormal or damaged proteins, which would otherwise accumulate and become harmful to the cell (reviewed in Pickart and Cohen, 2004).
Regulation of proteasome assembly and activity in health and
2018年7月31日 · The proteasome degrades most cellular proteins in a controlled and tightly regulated manner and thereby controls many processes, including cell cycle, transcription, signalling, trafficking and...
The proteasome: overview of structure and functions - PubMed
The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells.
Concept and application of circulating proteasomes - Nature
2021年10月27日 · The 26S proteasome, a unique ATP-dependent proteolytic complex in eukaryotic cells, contributes to the majority of intracellular proteolysis.
KEGG PATHWAY: Proteasome
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress …