Sanjeev Kumar the Binding Site

约 6,920,000 个结果

时间不限

在新选项卡中打开链接

Google Scholar
https://scholar.google.com › citations
‪Sanjeev Kumar‬ - ‪Google Scholar‬
Cross-neutralizing anti-HIV-1 human single chain variable fragments (scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library
PubMed
https://pubmed.ncbi.nlm.nih.gov
Novel HIV-1 capsid-targeting small molecules of the PF74 binding …
2020年10月15日 · The PF74 binding site in HIV-1 capsid protein (CA) is a compelling antiviral drug target. Although PF74 confers mechanistically distinct antiviral phenotypes by competing …
- 作者: Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Jayakanth Kankanala, Kare...
- Publish Year: 2020
PubMed
https://pubmed.ncbi.nlm.nih.gov
Novel PF74-like small molecules targeting the HIV-1 capsid
Molecular docking corroborated that 20 binds to the PF74 binding site, and revealed distinct binding interactions conferred by the benzamide moiety. Collectively, our data support …
- 作者: Lei Wang, Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Karen A. Kirby,...
- Publish Year: 2021
Sanjeev Kumar the Binding Site 的研究
PubMed
Novel HIV-1 capsid-targeting small molecules of the PF74 binding site
The PF74 binding site in HIV-1 capsid protein (CA) is a compelling antiviral drug target. Although PF74 confers mechanistically distinct antiviral phenotypes by competing against host factors for CA binding, it suffers from prohibitively low metabolic stability. Therefore, there has been increasing ...
作者: Lei Wang
已发布: 2020/10/15
Keywords: Capsid-targ…
PubMed
Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stabi...
作者: Lei Wang
已发布: 2021/3
Keywords: ART, antire…
PubMed
Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74
Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new...
作者: Rajkumar Lalji Sa…
已发布: 2021/03/15
Keywords: HIV-1; PF7…
National Center for Biotechnology Information
Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site
Although dozens of antivirals and fixed dose combinations [1] have been approved to treat the infection of human immunodeficiency virus type 1 (HIV-1), these drugs are not curative and HIV-1 remains a global healthcare challenge. Managing HIV-1 infection requires lifelong treatment, and hence, the v...
作者: Lei Wang, Mary …
已发布: 2020/10/10
DOI: 10.1016/j.ejmech.…
PubMed
Machine learning-based modulation of Ca2+-binding affinity in EF-hand proteins and comparative structural insights into site-specific cooperative binding
Ca2+-binding proteins are present in almost all living organisms and different types display different levels of binding affinities for the cation. Here, we report two new scoring schemes enabling the user to estimate and manipulate the calcium binding affinities in EF hand containing proteins. To v...
作者: Mohit Mazumder
已发布: 2023 Jul
Keywords: Ca(2+)-bin…
Google Scholar
https://scholar.google.com › citations
‪SANJEEV KUMAR‬ - ‪Google Scholar‬
Machine learning-based modulation of Ca2+-binding affinity in EF-hand proteins and comparative structural insights into site-specific cooperative binding
PubMed
https://pubmed.ncbi.nlm.nih.gov
Design, Synthesis and Characterization of HIV-1 CA-Targeting …
2021年3月15日 · Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 …
- 作者: Rajkumar Lalji Sahani, Raquel Diana-Rivero, Sanjeev Kumar V. Vernekar, Lei Wang, Haijuan Du, Huanchu...
- Publish Year: 2021
X-MOL科学知识平台
https://www.x-mol.com › paper
靶向HIV-1衣壳蛋白的新型PF74样小分子：效能和代谢稳定性的平衡
Lei Wang , Mary C. Casey , Sanjeev Kumar V. Vernekar , Rajkumar Lalji Sahani , Karen A. Kirby , Haijuan Du , Huanchun Zhang , Philip R. Tedbury , Jiashu Xie , Stefan G. Sarafianos , 在所有 …
ORCID
https://orcid.org
Sanjeev Kumar (0000-0002-8181-3999) - ORCID
Contributors: Sanjeev Kumar; Anamika Patel; Lilin Lai; Chennareddy Chakravarthy; ... CD4-Binding Site Directed Cross-Neutralizing scFv Monoclonals from HIV-1 Subtype C Infected …
ResearchGate
https://www.researchgate.net › profile
Sanjeev KUMAR | PostDoc Position | PhD - ResearchGate
Sanjeev KUMAR, PostDoc Position | Cited by 130 | of Vanderbilt University, TN (Vander Bilt) | Read 17 publications | Contact Sanjeev KUMAR
ResearchGate
https://www.researchgate.net › profile › Sanjeev-Kumar-Singh
Sanjeev Kumar Singh - ResearchGate
Sanjeev Kumar SINGH, Associate Professor | Cited by 3,665 | of Alagappa University, Kāraikkudi | Read 192 publications | Contact Sanjeev Kumar SINGH
Semantic Scholar
https://www.semanticscholar.org › paper
CD4-Binding Site Directed Cross-Neutralizing scFv Monoclonals …
2017年11月15日 · Three broadly neutralizing antibodies are identified, isolated from an HIV-1–infected individual, that exhibited great breadth and potency of neutralization and were …
分页
- 1
- 2
- 3
- 4
- 下一页