Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.

Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of innate immune responses. Since their discovery, ... Innate immunity is the first defense system against invading pathogens.

2024年11月23日 · Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system as well as the digestive system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes.

Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses.

Kagan and Fitzgerald comprehensively review the functions and mechanisms of Toll-like receptors (TLRs), which are crucial detectors of microbial biomolecules and mediators of cellular immunity. They synthesize the overarching themes that have emerged from TLR signaling but are repeated throughout the pattern recognition receptor (PRR) superfamily.

Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) that initiate the innate immune response by sensing conserved molecular patterns for early immune recognition of a pathogen . The typical TLRs are type I transmembrane proteins that contain three structural domains: a leucine-rich repeats (LRRs) motif, a ...

2004年7月1日 · Toll-like receptor (TLR)-signalling pathways are negatively regulated by several molecules that are induced by the stimulation of TLRs.

2024年4月9日 · Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs).

Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) which play a crucial in the initiation of innate immune response by detecting potential harmful pathogens. In mammals, the number of TLRs varies between species: human have 10 TLRs whereas mouse have 12 TLRs.