Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) [5] is a mitochondrial carrier protein found in brown adipose tissue (BAT).

Uncoupling protein 1 (UCP1) is an integral membrane protein found in the mitochondrial inner membrane of brown adipose tissue, and facilitates the process of non-shivering thermogenesis in mammals.

UCP-1 is a transmembrane protein localized in the inner mitochondrial membrane catalyzing the transport of protons across the mitochondrial membrane and thereby inducing mitochondrial uncoupling [7]. UCP-1 function is tightly regulated. First, purine nucleotides, such as GDP, directly bind UCP-1 and lead to its inactivation [8].

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ.

2011年12月27日 · Uncoupling protein 1 (UCP1), is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function performed by brown adipocytes.

2024年6月1日 · Uncoupling protein 1 (UCP1, SLC25A7) is a mitochondrial carrier that facilitates thermogenesis in brown adipose tissue (BAT) by dissipating the protonmotive force and is a potential target for therapeutics against metabolic disease.

2023年5月5日 · Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides...

UCP1 acts by uncoupling the process of substrate oxidation and ATP synthesis by allowing the protons to pass passively from the intermembrane space to the mitochondrial matrix through an alternative channel, dissipating the proton motive force without generation of ATP. Instead, the oxidized energy is released as heat (Figure 4). Figure 4.

Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter. An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial ...

The first uncoupling protein to be discovered, UCP1, indeed plays a crucial role in cold adaptation of mammals and in the body mass control of rodents. The discovery of UCP1 homologues named UCP2, UCP3 and the plant stUCP, strongly stimulated research in the …