Valproate - ALZFORUM
Valproate is an anti-convulsant and mood-stabilizing drug that is FDA- and EMA-approved to treat seizures, manic episodes associated with bipolar disorder, and to prevent migraine headaches. It is also used off-label for other psychiatric conditions.
Citalopram Calms Agitation in Alzheimer’s, but Carries Risks
Other alternatives tested so far, such as donepezil and antiepileptics like valproate, have failed to show a benefit (see Oct 2007 news story; Nov 2009 conference story). Previous studies hinted that citalopram, a selective serotonin reuptake inhibitor (SSRI), helped calm elderly patients who had dementia or anxiety (see, e.g., Nyth and ...
Therapeutics Search - ALZFORUM
Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AKST4290 AL002 AL003 AL044 AL101 …
Therapeutics | ALZFORUM
2015年11月25日 · Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 …
Therapeutics | ALZFORUM
2015年11月25日 · Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 …
Aberrant excitatory neuronal activity and compensatory
2007年11月20日 · Valproate seemed potentially useful because it is known to affect the brain. Along these lines, it could be considered that β amyloid could increase the excitability in neural networks, and reduction of that excitability could reduce the predilection for tauopathy to develop.
Salubrinal to the Rescue? New Compound Fights ER Stress
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci. 2005 Jan 1;118(Pt 1):89-99. PubMed. Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
Surprise: HDAC Goes Down, Not Up, in Alzheimer’s Disease
Vorinostat inhibits class I and class II HDACs. The McGill group has shared their data with the German investigators so they can take it into account. Notably, the class I HDAC inhibitor valproate was previously found ineffective for managing neuropsychiatric symptoms in AD, and it also associated with worse cognitive decline (Fleisher et al ...
A New Drug to Calm Agitation, Uncontrollable Laughing and
2014年10月21日 · Valproate; News Citations. Citalopram Calms Agitation in Alzheimer’s, but Carries Risks 21 Feb 2014; Paper Citations. Cruz MP. Nuedexta for the treatment of pseudobulbar affect: a condition of involuntary crying or laughing. P …
Does Lithium in Tap Water Keep Dementia at Bay? | ALZFORUM
2017年9月1日 · Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet. 2010 Jan 30;375(9712):385-95. Epub 2010 Jan 19 PubMed. Feyt C, Kienlen-Campard P, Leroy K, N'Kuli F, Courtoy PJ, Brion JP, Octave JN.