The naturally occurring phosphonate 2-aminoethylphosphonic acid was first identified in 1959 in plants and many animals, where it is localized in membranes. Phosphonates are quite common among different organisms, from prokaryotes to eubacteria and mushrooms , mollusks , …

Phosphonate salts (where M is a metal ion, e.g. sodium) Chemical formula of phophonic acids Chemical formula of phophonate salts

2019年6月27日 · Phosphonates are organophosphorus compounds characterized by a stable carbon-to-phosphorus (C—P) bond, which usually resists biochemical, thermal, and photochemical decomposition. The first phosphonate (compound 1, Figure 1), being an analog of β-alanine and taurine, was isolated in 1959 from ciliated protozoa in the rumen of sheep . That ...

Phosphonate esters have found a wide range of application in the areas of industrial, agricultural, and medicinal chemistry owing to their physical properties as well as their utility as synthetic intermediates.

2024年5月21日 · Occasionally called phosphites, a phosphonate is a salt or an ester of one of a family of phosphonic acids. The simplest — unsubstituted — phosphonic acid is H-(PO)-(OH) 2, a crystalline white solid obtained by reacting phosphorous trioxide with water.

Morita T., Okamoto Y., Sakurai H. Dealkylation reaction of acetals, phosphonate and phosphate esters with chlorotrimethylsilane/metal halide reagent in acetonitrile, and its application to the synthesis of phosphonic acids and vinyl phosphates.

2012年1月1日 · The phosphonate group can be used as the molecular tool in recognition and sensing of biologically relevant molecules, drug delivery and treatment, or as a linker between the inorganic and organic parts of a bio-device.

2016年10月27日 · Additionally, the phosphonate moiety represents a source of inorganic phosphate to microorganisms that live in environments that lack this nutrient; thus, unusual enzyme reactions have also evolved to cleave the C–P bond.

This review aims to guide readers through the fundamentals of nucleoside phosphonate therapeutics in order to inspire the future design of molecules to target infections that are refractory to currently available therapeutic options (Groaz and Jonghe).

2017年4月26日 · Additionally, the phosphonate moiety represents a source of inorganic phosphate to microorganisms that live in environments that lack this nutrient; thus, unusual enzyme reactions have also evolved to cleave the C-P bond.