Patients with malignant glioma usually have a poor prognosis due to drug resistance and disease relapse. Cancer stem cells contribute to glioma initiation, progression, resistance, and relapse. …

This cancer stem cell/tumor initiating cell population is optimally preserved and maintained in primary glioblastoma cultures. Here, we describe a method for the isolation and culture of …

2024年8月17日 · We identified that GPRC5A expression was significantly upregulated in GBM compared to normal tissues, with higher levels correlating with poor overall survival (OS) and …

2022年11月17日 · The novel data explain the inconsistencies in earlier glioma stem cell research and also provide insight into the development of more effective targeted therapy and the cell …

2009年6月5日 · In vitro expansion of the putative cancer stem cells as stable cell lines would provide a powerful model system to study their biology. Here, we demonstrate routine and …

2024年9月16日 · Glioma stem cells (GSCs), characterized by their stem cell attributes, constitute a minor subset within the larger glioma cell population. The majority of the glioma mass …

2023年12月24日 · The paracrine HGF secretion from neurons greatly facilitated glioma cells’ growth and development and chemotactic invasion in MET-positive cells. In addition, HGF also …

2020年6月4日 · Here, we employ a rapid 3D bioprinting system and photocrosslinkable native ECM derivatives to create a biomimetic 3D cancer microenvironment for the highly lethal brain …

2022年8月3日 · Glioblastoma multiforme (GBM) has a high rate of recurrence, which is in part due to residual tumor containing glioma stem cells (GSCs) after surgical debulking. To target these …

2024年4月3日 · Here we report that different molecular subtypes of human glioma stem cells (GSC) trigger distinct endothelial responses involving either angiogenic or circumferential …