Plasmin is a serine protease that acts to dissolve fibrin blood clots. Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system, and weakens the wall of the Graafian follicle, leading to ovulation. Plasmin is also integrally involved in inflammation. [6]

Plasmin is an alkaline serine proteinase that hydrolyzes α s1-casein, α s2-casein, and β-casein. The plasmin proteolytic system of milk consists of plasmin, plasminogen (PG), plasminogen activators (PA), plasminogen activator inhibitors (PAI) and plasmin inhibitors (PI).

Plasmin is a major fibrinolytic protease generated by converting its zymogen plasminogen by fibrinolytic activators in the presence or absence of fibrin. Plasminogen is synthesized primarily in the liver and circulates in plasma at a concentration of approximately 1.5 μmol/L [1].

2022年9月26日 · Plasminogen activation results in increased conversion of plasminogen to plasmin, the latter an enzyme that breaks down the fibrinogen in blood clots. There is a wide usage of tissue plasminogen activators in clinical practice during treating ischemic cerebral vascular events.

Plasmin is a broad-spectrum serine protease, responsible for fibrin degradation during thrombolysis. The proteolytic activity of plasmin contributes to a variety of normal and pathological processes that involve cell migration and/or tissue remodeling.

Plasmin is an autologous serum protease that is a key component of the fibrinolysis cascade. Plasmin is a non-specific protease usually present in human serum, and it is responsible for degrading a variety of plasma proteins; its specific physiologic role is to degrade fibrin clots.

Plasmin is a proteolytic enzyme—a substance that causes breakdown of proteins—derived from an inert plasma precursor known as plasminogen. When clots are formed within blood vessels, activation of plasminogen to plasmin may lead to their removal.