Best ways to make your botox last longer 👉7 practical tips. I often hear patients say, my botox doesn't last as long as it did when i was younger. Botox in your 20s and 30s is not the same as your 40s and fifties. This is because we have less collagen, elastin and subcutaneous fat. Basically our skin is thinner. These things can help. 1. sunscreen 2. retinol 3. collagen stimulating treatments 4. zinc suplements 5. skin boosting treatments 6. staying hydrated 7. HA fillers #antiaging #antiwrinkl